The Oh Lab

Dr. Oh’s lab focuses on the mechanisms underlying disease onset in neurodegenerative diseases through miRNA-mediated neuronal reprogramming, which has the potential to yield valuable insights into their underlying causes. By generating reprogrammed neurons from patient-derived fibroblasts and investigating the role of miRNAs in neuronal subtype generation, Dr. Oh’s lab aims to recapitulate disease pathology while preserving age- and disease-related characteristics. This approach could provide a valuable platform for understanding why neurodegenerative diseases manifest later in life and for identifying the factors that drive their onset.